The Vanderbilt group have just published the results of the feasibility trial MIND - Modifying the INcidence of Delirium in Critical Care Medicine. It is important because it was a placebo trial comparing ICU delirium duration using haloperidol, ziprasidone and placebo. While there was no difference between the groups it demonstrated safety and feasibility of such a study. The doors are open for a larger trial powered for meaningful outcomes.

http://journals.lww.com/ccmjournal/Abstract/publishahead/Feasibility,_efficacy,_and_safety_of.98817.aspx