Given the evidence to date, limited though it is, should we be giving prophylactic haloperidol to all our critically ill patients?  Read the thought-provoking letter in August Critical Care Medicine “The largest ever trial demonstrating effectiveness of intensive care delirium prophylaxis-We must know more!”* written by Dr Reade to find out the questions that need answering first.  CCM 2012;40:2540

*Wang et al CCM 2012;40:731-739: for a summary see the latest Annals of Delirium on the European Delirium Association website