Drugs may be considered as the most easily reversible trigger factor; most common are benzodiazepines, anticholinergic drugs and high dose narcotics.
Analgesics:
Codeine
Fentanyl
Morphine
Pethidine
Antidepressants:
Amitryptyline
Paroxetine
Anticonvulsants:
Phenytoin
Antihistamines:
Chlorphenamine
Promethazine
Antiemetics:
Prochlorperazine
Benzodiazepines:
Midazolam
Lorazepam
Cardiovascular agents:
Atenolol
Digoxin
Dopamine
Lidocaine
Corticosteroids
Furosemide
Ranitidine
sir/madam
after compliments
am working at dubai.
do you have a standard drug strategy for sedating patients on mechanical ventilator? we always use a combination of dormicum+fentanyl/morphine for sedating patients during mechanical ventilation and we find >80% of patients becomes agitated and very restless on extubation. we uses haloperidol+ dormicum to control them. if you can highlight on these, it will be highly useful
thanking you
dr Pramod
Its not so much what you use as how you use it. A fairly basic article in Care of the Critically Ill. December 2008 Volume 24.6 describes the use of sedation scores with sedation breaks or “holidays”. Midazolam, while having useful proporties for sedation, is deliriogenic. The Intensive Care Society are due to produce new guidelines on sedation. In the meantime more analgesia, less sedative drug and monitor for delirium. Good luck!